Suspect novel adverse drug reactions to trimethoprim-sulphonamide combinations in horses: A case series

Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at...

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Bibliographic Details
Published in:Equine veterinary journal 2011, Vol.43 (1), p.117-120
Main Authors: Stack, A, Schott, H.C. II
Format: Article
Language:English
Subjects:
adverse drug reaction
adverse effects
agitation
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
blood
Central Nervous System Diseases - chemically induced
Central Nervous System Diseases - veterinary
Consumer protection
Drug Overdose
drug therapy
Drug Therapy, Combination
Female
foals
gait
gastrointestinal system
horse
Horse Diseases - chemically induced
Horses
hyperaesthesia
hypermetria
Male
neurological deficits
overdose
Pharmaceutical industry
Pyrimethamine - administration & dosage
Pyrimethamine - adverse effects
Side effects
Sulfadiazine - administration & dosage
Sulfadiazine - adverse effects
Sulfamethoxazole - administration & dosage
Sulfamethoxazole - adverse effects
Sulfonamides - administration & dosage
Sulfonamides - adverse effects
Trimethoprim - administration & dosage
Trimethoprim - adverse effects
trimethoprim‐sulphonamide drugs
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Summary:Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.
ISSN:0425-1644
2042-3306
DOI:10.1111/j.2042-3306.2010.00158.x