Multifunctional Dendrimer-Modified Multiwalled Carbon Nanotubes: Synthesis, Characterization, and In Vitro Cancer Cell Targeting and Imaging

Carbon nanotubes hold great promise for their use as a platform in nanomedicine, especially in drug delivery, medical imaging, and cancer targeting and therapeutics. Herein, we present a facile approach to modifying carbon nanotubes with multifunctional poly(amidoamine) (PAMAM) dendrimers for cancer...

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Bibliographic Details
Published in:Biomacromolecules 2009-07, Vol.10 (7), p.1744-1750
Main Authors: Shi, Xiangyang, Wang, Su He, Shen, Mingwu, Antwerp, Mary E, Chen, Xisui, Li, Chang, Petersen, Elijah J, Huang, Qingguo, Weber, Walter J, Baker, James R
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Composites
Dendrimers - chemistry
Dendrimers - therapeutic use
Diagnostic Imaging
Drug Delivery Systems - methods
Exact sciences and technology
Forms of application and semi-finished materials
General pharmacology
Humans
Medical sciences
Nanotubes, Carbon - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymer industry, paints, wood
Technology of polymers
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Summary:Carbon nanotubes hold great promise for their use as a platform in nanomedicine, especially in drug delivery, medical imaging, and cancer targeting and therapeutics. Herein, we present a facile approach to modifying carbon nanotubes with multifunctional poly(amidoamine) (PAMAM) dendrimers for cancer cell targeting and imaging. In this approach, fluorescein isothiocyanate (FI)- and folic acid (FA)-modified amine-terminated generation 5 (G5) PAMAM dendrimers (G5·NH2-FI-FA) were covalently linked to acid-treated multiwalled carbon nanotubes (MWCNTs), followed by acetylation of the remaining primary amine groups of the dendrimers. The resulting MWCNT/G5.NHAc-FI-FA composites are water-dispersible, stable, and biocompatible. In vitro flow cytometry and confocal microscopy data show that the formed MWCNT/G5·NHAc-FI-FA composites can specifically target to cancer cells overexpressing high-affinity folic acid receptors. The results of this study suggest that, through modification with multifunctional dendrimers, complex carbon nanotube-based materials can be fabricated, thereby providing many possibilities for various applications in biomedical sensing, diagnosis, and therapeutics.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm9001624