Erythrocyte Deformation in Human Muscular Dystrophy

Erythrocytes from patients with congenital muscular dystrophy exhibit dramatic surface deformation when observed with a scanning electron microscope. A similar alteration, but one affecting a smaller proportion of cells, occurs in the case of female carriers of the sex-linked Duchenne dystrophic con...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1974-04, Vol.184 (4133), p.165-166
Main Authors: Matheson, Dale W., Howland, John L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Blood
Cell membranes
Charge carriers
Child
Erythrocyte membrane
Erythrocytes
Ethanol
Female
Genetic Linkage
Humans
Infant
Male
Microscopy, Electron, Scanning
Middle Aged
Muscular diseases
Muscular dystrophies
Muscular Dystrophies - blood
Muscular Dystrophies - congenital
Muscular Dystrophies - genetics
Nervous system diseases
Observational research
Sex Chromosomes
Sex Factors
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Description
Summary:Erythrocytes from patients with congenital muscular dystrophy exhibit dramatic surface deformation when observed with a scanning electron microscope. A similar alteration, but one affecting a smaller proportion of cells, occurs in the case of female carriers of the sex-linked Duchenne dystrophic condition. These observed changes in the erythrocyte surface may reflect a systemic defect in membrane properties.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.184.4133.165