Relevant Anion-π Interactions in Biological Systems: The Case of Urate Oxidase

Enzyme inhibited: The important role of anion–π interactions that are present in the active site of the urate oxidase enzyme is reported (see picture). The inhibition of this enzyme by cyanide ions is caused by the existence of an anion–π interaction between the inhibitor and the enzymatic substrate...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-01, Vol.50 (2), p.415-418
Main Authors: Estarellas, Carolina, Frontera, Antonio, Quiñonero, David, Deyà, Pere M.
Format: Article
Language:English
Subjects:
ab initio calculations
anion-π interactions
Anions - chemistry
Binding Sites
Catalytic Domain
Cyanides - chemistry
donor-acceptor systems
enzyme models
Models, Molecular
Static Electricity
supramolecular chemistry
Urate Oxidase - chemistry
Urate Oxidase - metabolism
Uric Acid - metabolism
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Summary:Enzyme inhibited: The important role of anion–π interactions that are present in the active site of the urate oxidase enzyme is reported (see picture). The inhibition of this enzyme by cyanide ions is caused by the existence of an anion–π interaction between the inhibitor and the enzymatic substrate. This investigation extends the relevance of anion–π interactions to important fields such as enzyme chemistry.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201005635