Water-Soluble Peptide-Coated Nanoparticles: Control of the Helix Structure and Enhanced Differential Binding to Immune Cells

The stabilizing action of Cα-tetrasubstituted α-amino acids inserted into a sequence of short peptides allowed for the first time the preparation of water-soluble nanoparticles of different materials coated with a helix-structured undecapeptide. This peptide coating strongly favors nanoparticle upta...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2011-01, Vol.133 (1), p.8-11
Main Authors: Rio-Echevarria, Iria M, Tavano, Regina, Causin, Valerio, Papini, Emanuele, Mancin, Fabrizio, Moretto, Alessandro
Format: Article
Language:English
Subjects:
HeLa Cells
Humans
Immune System - cytology
Macrophages - metabolism
Models, Molecular
Monocytes - metabolism
Nanoparticles - chemistry
Peptides - chemistry
Peptides - metabolism
Protein Binding
Protein Structure, Secondary
Siloxanes - chemistry
Solubility
Substrate Specificity
Water - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The stabilizing action of Cα-tetrasubstituted α-amino acids inserted into a sequence of short peptides allowed for the first time the preparation of water-soluble nanoparticles of different materials coated with a helix-structured undecapeptide. This peptide coating strongly favors nanoparticle uptake by human immune system cells.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja107588q