Cyclical Granulopoiesis in Chronic Granulocytic Leukemia: A Simulation Study

There exists ample evidence that granulopoiesis is an actively controlled process. The observation of cyclical granulopoiesis in chronic granulocytic leukemia (CGL) suggests that control is deranged rather than abolished in this disorder. Analysis of the kinetics of granulopoiesis in CGL may provide...

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Bibliographic Details
Published in:Blood 1974-03, Vol.43 (3), p.379-387
Main Authors: Wheldon, T.E., Kirk, J., Finlay, Helen M.
Format: Article
Language:English
Subjects:
Blood Cell Count
Computers, Analog
Hematopoiesis
Hematopoietic Stem Cells
Humans
Kinetics
Leukemia, Myeloid - blood
Leukocytosis
Leukopenia
Models, Biological
Periodicity
Time Factors
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Summary:There exists ample evidence that granulopoiesis is an actively controlled process. The observation of cyclical granulopoiesis in chronic granulocytic leukemia (CGL) suggests that control is deranged rather than abolished in this disorder. Analysis of the kinetics of granulopoiesis in CGL may provide some insight into the nature of the derangement. To facilitate analysis, a mathematical model of the granulopoietic control system is proposed and examined using computer simulation. With model parameters initially chosen to represent normal granulopoiesis, the minimal changes necessary to represent granulopoiesis in CGL were investigated. This analysis indicates that two separate changes seem to be required: (1) the granulocyte maturation time must be increased and (2) the precursor input to the granulocytic pathway of development must also be increased. A causal association between delayed maturation and rising precursor input is suggested, and some possible mechanisms of association are proposed.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V43.3.379.379