Ecto-Enzyme of Granulocytes: 5′-Nucleotidase

The 5′nucleotidase of guinea pig polymorphonuclear leukocytes is localized exclusively on the plasma membrane of intact cells. The active site of this enzyme faces the external medium, not the cytoplasm.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1974-03, Vol.183 (4129), p.1096-1098
Main Authors: DePierre, Joseph W., Karnovsky, Manfred L.
Format: Article
Language:English
Subjects:
Adenosine Monophosphate - metabolism
Amines - pharmacology
Animals
Benzenesulfonates - pharmacology
Binding Sites
Cell Membrane - enzymology
Cell membranes
Chemical suspensions
Diazonium Compounds - pharmacology
Edetic Acid - pharmacology
Enzymes
Guinea Pigs
Hydrolysis
L-Lactate Dehydrogenase - blood
Lactates
Leukocytes - cytology
Leukocytes - enzymology
Lymphocytes
Neutrophils
Nucleotidases - antagonists & inhibitors
Nucleotidases - blood
Phosphatases
Phosphates
Phosphorus Radioisotopes
Reagents
Sulfhydryl Reagents - pharmacology
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Description
Summary:The 5′nucleotidase of guinea pig polymorphonuclear leukocytes is localized exclusively on the plasma membrane of intact cells. The active site of this enzyme faces the external medium, not the cytoplasm.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.183.4129.1096