Reaction of Haloperidol with 5-(Hydroxymethyl)-2-furfuraldehyde, an Impurity in Anhydrous Lactose

In the investigation of haloperidol direct compression tablets, using anhydrous lactose as one excipient, a 5–8% loss was encountered on initial assays. Analysis of the lactose by UV, GLC, and mass spectrometry confirmed the presence of 5-(hydroxymethyl)-2-furfuraldehyde. Haloperidol was reacted wit...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1974-01, Vol.63 (1), p.41-43
Main Authors: Janicki, Casimir A., Almond, Harold R.
Format: Article
Language:English
Subjects:
5-(Hydroxymethyl)-2-furfuraldehyde as impurity in anhydrous lactose- reactions with haloperidol
anhydrous
Capsules - analysis
Chemical Phenomena
Chemistry
Chromatography, Gas
containing 5-(hydroxymethyl)-2-furfuraldehyde as contaminant-reaction with haloperidol
Drug Contamination
Furaldehyde
Haloperidol - analysis
Haloperidol-reaction with 5-(Hydroxymethyl)-2-furfuraldehyde impurity in anhydrous lactose
Lactose
Lactose, anhydrous, containing 5-(hydroxymethyl)-2-furfuraldehyde as contaminant—reaction with haloperidol
Magnetic Resonance Spectroscopy
Mass Spectrometry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tablets - analysis
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Summary:In the investigation of haloperidol direct compression tablets, using anhydrous lactose as one excipient, a 5–8% loss was encountered on initial assays. Analysis of the lactose by UV, GLC, and mass spectrometry confirmed the presence of 5-(hydroxymethyl)-2-furfuraldehyde. Haloperidol was reacted with 5-(hydroxymethyl)-2-furfuraldehyde and furfural, and conversion to addition compounds resulted. Although both addition compounds were characterized, they could not be isolated from the direct compression tablets.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600630110