The Intravascular Survival of Neutrophils Labeled In Vivo

The survival of blood neutrophils labeled in vivo was studied in the calf. Disappearance of labeled neutrophils from the blood of calves was followed after a period of cross circulation with their chimeric, immunologically tolerant twins, which had been given tritiated thymidine 6 1/2 days previousl...

Full description

Saved in:
Bibliographic Details
Published in:Blood 1974-03, Vol.43 (3), p.371-377
Main Authors: Vincent, Paul C., Chanana, Arjun D., Cronkite, Eugene P., Joel, Darrel D.
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Cattle
Cell Survival
Female
Half-Life
Hydrocortisone - pharmacology
Injections, Intravenous
Isotope Labeling
Neutrophils - drug effects
Parabiosis
Pregnancy
Skin Transplantation
Thymidine - metabolism
Transplantation, Homologous
Tritium
Twins
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The survival of blood neutrophils labeled in vivo was studied in the calf. Disappearance of labeled neutrophils from the blood of calves was followed after a period of cross circulation with their chimeric, immunologically tolerant twins, which had been given tritiated thymidine 6 1/2 days previously. Under these conditions, neutrophils were shown to leave the blood in a random exponential fashion, with half-disappearance times of between 6.4 and 7.5 hr. Hydrocortisone given to one calf 48 hr after cross circulation caused a neutrophilic leukocytosis, during which substantial numbers of labeled neutrophils reappeared in the blood.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V43.3.371.371