Bilirubin Inhibition of Heme Biosynthesis

The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. Implications of th...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1959-06, Vol.129 (3365), p.1741-1742
Main Authors: Labbe, Robert F., Zaske, Merlin R., Aldrich, Robert A.
Format: Article
Language:English
Subjects:
Animals
Bilirubin - pharmacology
Biochemical Phenomena
Biosynthesis
Enzymes
Heme
Hemoglobins
Hyperbilirubinemia
Iron
Kinetics
Liver
Liver - metabolism
Old Medline
Oxidation
Protoporphyrins
Rats
Snow
Stratosphere
Troposphere
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Summary:The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. Implications of this finding in hyperbilirubinemia are mentioned.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.129.3365.1741