Synergistic Response between Thymus and Lymph Node Cells in the Mixed Lymphocyte Culture

IN rodents the mixed lymphocyte culture (MLC) reaction probably represents an in vitro model of the graft versus host (GvH) response 1 . Thymus-dependent lymphoid cells (T cells) are thought to be responsible for both reactions 2,3 . Cantor and Asofsky 4,5 presented evidence for the synergistic inte...

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Bibliographic Details
Published in:Nature (London) 1974-02, Vol.247 (5440), p.371-373
Main Authors: TITTOR, WOLFGANG, WALFORD, ROY L
Format: Article
Language:English
Subjects:
Animals
Humanities and Social Sciences
letter
Lymph Nodes - cytology
Lymph Nodes - immunology
Lymphocyte Activation - drug effects
Lymphocyte Culture Test, Mixed
Lymphocytes - immunology
Lymphocytes - metabolism
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mitomycins - pharmacology
multidisciplinary
Science
Science (multidisciplinary)
Spleen - cytology
Spleen - immunology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Thymidine - metabolism
Tritium
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Summary:IN rodents the mixed lymphocyte culture (MLC) reaction probably represents an in vitro model of the graft versus host (GvH) response 1 . Thymus-dependent lymphoid cells (T cells) are thought to be responsible for both reactions 2,3 . Cantor and Asofsky 4,5 presented evidence for the synergistic interaction of two thymus-dependent lymphocyte populations in the GvH response. In their studies one cell type (amplifier cells or T 2 cells) was obtained from the peripheral circulation, the other type (precursor cell or T 1 cell) was found in greatest concentration in the thymus and spleen. A mixture of thymocytes and peripheral blood lymphocytes produced a GvH reaction significantly greater than was expected from summation of the separate reactivities of the components of the mixture. This ‘synergy’ occurred only when both cell populations had been obtained from donors allogeneic to the host 4 .
ISSN:0028-0836
1476-4687
DOI:10.1038/247371a0