Amino acid sequence change associated with genetic marker Inv(2) of human immunoglobulin

IMMUNOGLOBULINS are proteins composed of two heavy and two light chains covalently linked by interchain disulphide bonds 1 . There are two types of light chains, κ and λ. The κ type human light chain is associated with an antigenic marker called Inv (ref. 2). Three types of antigens are recognised n...

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Bibliographic Details
Published in:Nature (London) 1974-03, Vol.248 (5444), p.160-161
Main Authors: MILSTEIN, CELIA P, STEINBERG, A. G, MCLAUGHLIN, CARLA L, SOLOMON, A
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Bence Jones Protein - analysis
Epitopes
Female
Genes
Genetic Code
Genotype
Humanities and Social Sciences
Humans
Immunoglobulin Fragments - analysis
letter
Male
multidisciplinary
Pedigree
Phenotype
Science
Science (multidisciplinary)
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Summary:IMMUNOGLOBULINS are proteins composed of two heavy and two light chains covalently linked by interchain disulphide bonds 1 . There are two types of light chains, κ and λ. The κ type human light chain is associated with an antigenic marker called Inv (ref. 2). Three types of antigens are recognised namely Inv (1), Inv(2) and Inv(3). Ropartz, Rivat and Rousseau 3 have shown that these Inv markers are inherited through a series of three alleles Inv 1,2 , Inv 1 and Inv 3 . About 98% of Caucasoid individuals who have the Inv(1) antigen also have the Inv (2) antigen 3 . Since fewer than 20% Cauca-soids have the Inv(1, −2) phenotype 4 it follows that the Inv 1 allele is rare in this race.
ISSN:0028-0836
1476-4687
DOI:10.1038/248160a0