Effect of Multiple Doses of Cadmium on Glucose Metabolism in the Rat

The effect of multiple doses of cadmium on carbohydrate metabolism in rats was studied. The treated groups received two dose levels, 0.25 and 0.50mg cadmium/kg ip every 2nd day for 20 doses. Plasma glucose, immunoresponsive insulin levels, and body weights were determined before treatment and after...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1974-01, Vol.63 (1), p.146-149
Main Authors: Ithakissios, Dionyssis S., Kessler, Wayne V., Arvesen, James N., Born, Gordon S.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Blood Glucose
Cadmium - administration & dosage
Cadmium - metabolism
Cadmium - pharmacology
Cadmium-effect of multiple doses on glucose metabolism
Cadmium—effect of multiple doses on glucose metabolism, rat
Carbon Dioxide - metabolism
Carbon Radioisotopes
Dose-Response Relationship, Drug
Female
Glucose - metabolism
Glucose metabolism-effect of multiple doses of cadmium
Glucose metabolism—effect of multiple doses of cadmium, rat
Glycolysis-possible effect of multiple doses of cadmium on glucose metabolism
Glycolysis—possible effect of multiple doses of cadmium on glucose metabolism, rat
Insulin - blood
Insulin Antibodies - analysis
Iodine Radioisotopes
Kidney - metabolism
Pancreas - metabolism
Radioimmunoassay
rat
Rats
Spleen - metabolism
Time Factors
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Summary:The effect of multiple doses of cadmium on carbohydrate metabolism in rats was studied. The treated groups received two dose levels, 0.25 and 0.50mg cadmium/kg ip every 2nd day for 20 doses. Plasma glucose, immunoresponsive insulin levels, and body weights were determined before treatment and after 10 and 20 doses of cadmium. After the last dosage, D-glucose-14C (uniformly labeled) was administered to a randomly chosen subgroup and a carbon dioxide radiorespirometry experiment was performed. Statistically significant differences in blood glucose and insulin levels were not detected at any time, indicating no effect of cadmium on the pancreatic secretory activity. There was no effect on body weights. However, cadmium increased the evolution of respiratory 14CO2. It is postulated that cadmium affects the rate of glucose metabolism in vivo by affecting mechanisms such as glycolysis and the tricarboxylic acid cycle.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600630141