Regional Coronary Venous Oxygen Saturation and Myocardial Oxygen Tension following Abrupt Changes in Ventricular Pressure in the Isolated Dog Heart

Regional coronary venous oxygen saturation and myocardial oxygen tension (PO2) in isolated dog hearts were measured using two different methods—a new technique of microscopic oximetry and an improved oxygen electrode. Both methods yielded similar results. In studies of the isolated perfused dog hear...

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Bibliographic Details
Published in:Circulation research 1974-05, Vol.34 (5), p.672-681
Main Authors: GAMBLE, WALTER J, LAFARGE, C GRANT, FYLER, DONALD C, WEISUL, JONATHAN, MONROE, R GRIER
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Coronary Vessels
Dogs
Electrodes, Implanted
Endocardium - blood supply
Heart Ventricles
In Vitro Techniques
Ischemia
Methods
Myocardium - metabolism
Oximetry - instrumentation
Oxygen - blood
Oxygen Consumption
Partial Pressure
Transducers
Veins
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Summary:Regional coronary venous oxygen saturation and myocardial oxygen tension (PO2) in isolated dog hearts were measured using two different methods—a new technique of microscopic oximetry and an improved oxygen electrode. Both methods yielded similar results. In studies of the isolated perfused dog heart developing a constant left ventricular systolic pressure, mean coronary venous oxygen saturation of blood in the subendocardial veins of the left ventricle was significantly lower than that in the subepicardial veins. Following abrupt increases in systolic pressure, subendocardial coronary venous saturations fell to even lower levels. Following abrupt decreases in systolic pressure, the mean subendocardial coronary venous oxygen saturation increased to levels above those in the blood of the subepicardial veins. These findings agree with the hypothesis that transient underperfusion and overperfusion of the subendocardial layers of the left ventricle occur with abrupt increases and decreases in ventricular pressure, respectively.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.34.5.672