Variation of Sensitivity to Ionizing Radiation with Age

THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams 1 found a maximum mort...

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Bibliographic Details
Published in:Nature (London) 1959-06, Vol.183 (4677), p.1729-1730
Main Authors: CROSFILL, M. L, LINDOP, PATRICIA J, ROTBLAT, J
Format: Article
Language:English
Subjects:
Aging
Humanities and Social Sciences
Humans
letter
multidisciplinary
Old Medline
Radiation Effects
Radiation, Ionizing
Science
Science (multidisciplinary)
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Summary:THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams 1 found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett 2 measured the LD 50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher 3 for mice. We are carrying out a systematic study 4 of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage the LD 50 at 30 days.
ISSN:0028-0836
1476-4687
DOI:10.1038/1831729a0