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Variation of Sensitivity to Ionizing Radiation with Age
THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams 1 found a maximum mort...
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| Published in: | Nature (London) 1959-06, Vol.183 (4677), p.1729-1730 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c369t-a0c18a3a758094a05efffcbdaee26aa93273303a2d274de7a60886609a363b693 |
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| cites | cdi_FETCH-LOGICAL-c369t-a0c18a3a758094a05efffcbdaee26aa93273303a2d274de7a60886609a363b693 |
| container_end_page | 1730 |
| container_issue | 4677 |
| container_start_page | 1729 |
| container_title | Nature (London) |
| container_volume | 183 |
| creator | CROSFILL, M. L LINDOP, PATRICIA J ROTBLAT, J |
| description | THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams
1
found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett
2
measured the
LD
50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher
3
for mice. We are carrying out a systematic study
4
of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage the
LD
50 at 30 days. |
| doi_str_mv | 10.1038/1831729a0 |
| format | article |
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1
found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett
2
measured the
LD
50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher
3
for mice. We are carrying out a systematic study
4
of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage the
LD
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1
found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett
2
measured the
LD
50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher
3
for mice. We are carrying out a systematic study
4
of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage the
LD
50 at 30 days.</description><subject>Aging</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Radiation Effects</subject><subject>Radiation, Ionizing</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><recordid>eNpt0M1LwzAYx_EgipvTg_-A9iQoVJ80XZIex_BlMBB8u5ZnbToztmQm6WT-9VZatounHPLhC8-PkHMKtxSYvKOSUZFkCAekT1PB45RLcUj6AImMQTLeIyfeLwBgSEV6THqUcd4Q1ifiA53GoK2JbBW9KuN10BsdtlGw0cQa_aPNPHrBskPfOnxGo7k6JUcVLr06694BeX-4fxs_xdPnx8l4NI0LxrMQIxRUIkMxlJClCENVVVUxK1GphCNmLBGMAcOkTERaKoEcpOQcMmSczXjGBuSq7a6d_aqVD_lK-0Itl2iUrX0uEyZTkaUNvG5h4az3TlX52ukVum1OIf9bKd-t1NiLLlrPVqrcy26WBty0wDdfZq5cvrC1M82h_9YuW2ww1E7tazvxC3VCeGI</recordid><startdate>19590620</startdate><enddate>19590620</enddate><creator>CROSFILL, M. L</creator><creator>LINDOP, PATRICIA J</creator><creator>ROTBLAT, J</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19590620</creationdate><title>Variation of Sensitivity to Ionizing Radiation with Age</title><author>CROSFILL, M. L ; LINDOP, PATRICIA J ; ROTBLAT, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-a0c18a3a758094a05efffcbdaee26aa93273303a2d274de7a60886609a363b693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Aging</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Radiation Effects</topic><topic>Radiation, Ionizing</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CROSFILL, M. L</creatorcontrib><creatorcontrib>LINDOP, PATRICIA J</creatorcontrib><creatorcontrib>ROTBLAT, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CROSFILL, M. L</au><au>LINDOP, PATRICIA J</au><au>ROTBLAT, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variation of Sensitivity to Ionizing Radiation with Age</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1959-06-20</date><risdate>1959</risdate><volume>183</volume><issue>4677</issue><spage>1729</spage><epage>1730</epage><pages>1729-1730</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams
1
found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett
2
measured the
LD
50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher
3
for mice. We are carrying out a systematic study
4
of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage the
LD
50 at 30 days.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13666873</pmid><doi>10.1038/1831729a0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1959-06, Vol.183 (4677), p.1729-1730 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82384794 |
| source | Nature Journals |
| subjects | Aging Humanities and Social Sciences Humans letter multidisciplinary Old Medline Radiation Effects Radiation, Ionizing Science Science (multidisciplinary) |
| title | Variation of Sensitivity to Ionizing Radiation with Age |
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