Synthesis of Human Placental Alkaline Phosphatase in Vitro by the ChaGo Cell Line

Human placental alkaline phosphatase was purified from an epithelial cell line which also synthesizes chorionic gonadotropin in vitro. The ChaGo alkaline phosphatase was immunochemically, biochemically, and functionally very similar to the alkaline phosphatase synthesized by the original tumor tissu...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1974-06, Vol.52 (6), p.1705-1709
Main Authors: Ludueña, Marilyn A., Sussman, Howard H., Rabson, Alan S.
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - analysis
Alkaline Phosphatase - biosynthesis
Cell Line
Cells, Cultured - drug effects
Chorionic Gonadotropin - biosynthesis
Chromatography, DEAE-Cellulose
Chromatography, Gel
Electrophoresis, Polyacrylamide Gel
Hormones, Ectopic - biosynthesis
Hot Temperature
Humans
Immunoassay
Leucine - pharmacology
Lung Neoplasms - enzymology
Molecular Weight
Phenylalanine - pharmacology
Placenta - enzymology
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Description
Summary:Human placental alkaline phosphatase was purified from an epithelial cell line which also synthesizes chorionic gonadotropin in vitro. The ChaGo alkaline phosphatase was immunochemically, biochemically, and functionally very similar to the alkaline phosphatase synthesized by the original tumor tissue and by normal placentas
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/52.6.1705