The chemotherapy of colorectal cancer

5‐fluorouracil remains the single chemotherapeutic agent that produces effective palliation in advanced colorectal carcinoma. Other drugs and combinations with 5‐FU often produce increased and sometimes excessive toxicity and offer no advantage over 5‐FU alone. Further observations of patients recei...

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Bibliographic Details
Published in:Cancer 1974-09, Vol.34 (S3), p.972-976
Main Author: Leone, Louis A.
Format: Article
Language:English
Subjects:
Administration, Oral
Colonic Neoplasms - drug therapy
Drug Therapy, Combination
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Humans
Infusions, Parenteral
Injections, Intravenous
Palliative Care
Rectal Neoplasms - drug therapy
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Summary:5‐fluorouracil remains the single chemotherapeutic agent that produces effective palliation in advanced colorectal carcinoma. Other drugs and combinations with 5‐FU often produce increased and sometimes excessive toxicity and offer no advantage over 5‐FU alone. Further observations of patients receiving adjuvant chemotherapy with 5‐fluorouracil are needed before we can be certain of improved 5‐ or 10‐year survivorship over that achieved by surgery alone.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197409)34:3+<972::AID-CNCR2820340729>3.0.CO;2-T