THE EFFECT OF DIET ON HEPATIC CHOLESTEROL SYNTHESIS IN ALLOXAN DIABETIC RATS

The effect of dietary composition on cholesterol formation in the liver of alloxan diabetic rats was studied. Cholesterol formation in these animals was maintained at a subnormal level when the diet had a high content of simple sugar (sucrose, glucose or fructose) without fat, but was severely impai...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 1974, Vol.20(1), pp.71-79
Main Authors: NAKABOU, Yukihiro, FUJIMOTO, Mayumi, OKITA, Chiyo, TAKANO, Yasuo, HAGIHIRA, Hiroshi
Format: Article
Language:English
Subjects:
Animals
Cholesterol - biosynthesis
Cholesterol - blood
Diabetes Mellitus, Experimental - metabolism
Diet
Dietary Carbohydrates - metabolism
Fructose - metabolism
Glucose - metabolism
Liver - metabolism
Male
Rats
Sucrose - metabolism
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Summary:The effect of dietary composition on cholesterol formation in the liver of alloxan diabetic rats was studied. Cholesterol formation in these animals was maintained at a subnormal level when the diet had a high content of simple sugar (sucrose, glucose or fructose) without fat, but was severely impaired with diets of all other compositions tested. The possible mechanism of maintenance of hepatic cholesterol synthesis in diabetic rats on a diet with a high content of simple sugar without fat is discussed. The rate of cholesterol synthesis in the liver was not always proportional to the plasma cholesterol level.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.20.71