Correlation Between Yoshida Sarcoma and Human Neoplastic Disease In Cancer Chemotherapy Studies

Experimental and clinical cancer chemotherapy studies with Yoshida sarcoma in rats and in 61 inoperable or advanced cancer patients are reported. The chemicals used were colchicine derivatives, p-phenylenediphosphoric acid tetraethyleneimid (RC4), and 1-thia-3-azaazulan-2-one (Az.). In these studies...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1959-07, Vol.23 (1), p.21-50
Main Authors: Katsura, Shigetsugu, Sato, Ko, Akaishi, Kenichi, Harada, Kazuhiro, Sato, Rintaro
Format: Article
Language:English
Subjects:
Animals
Humans
Neoplasms - therapy
Old Medline
Sarcoma, Yoshida
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Summary:Experimental and clinical cancer chemotherapy studies with Yoshida sarcoma in rats and in 61 inoperable or advanced cancer patients are reported. The chemicals used were colchicine derivatives, p-phenylenediphosphoric acid tetraethyleneimid (RC4), and 1-thia-3-azaazulan-2-one (Az.). In these studies, combination chemotherapy with RC4 and Az. showed the best results. The combined use of 2 substances which have entirely different modes of action prevented growth of resistant tumor cells, and effective treatment by a small amount of long-term continued injections on tumor cells was substantiated. A number of patients with carcinoma of the breast, lung, and digestive tract showed objective or subjective improvement by the combination chemotherapy. If properly used, chemotherapy appears to have merit as an additive method in conjunction with surgical intervention in the treatment of certain types of inoperable and metastatic cancer, though a high rate of long-term survivors was not obtained with the present combination chemotherapy.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/23.1.21