Effect of panax ginseng root on spontaneous movement and exercise in mice

• Published in: Japanese journal of pharmacology 1974, Vol.24 (1), p.41-48
• Main Authors: TAKAGI, Keijiro, SAITO, Hiroshi, TSUCHIYA, Moriyoshi
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Caffeine - pharmacology; Locomotion - drug effects; Male; Meprobamate - pharmacology; Methamphetamine - pharmacology; Mice; Movement - drug effects; Panax; Physical Exertion - drug effects; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plants, Medicinal
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)32105-5

Effects on motor activities of normal and exhausted mice were studied on fractions obtained from Panax Ginseng root consecutively administered orally in small doses. Effects on motor activities were measured utilizing: hole cross (HC) test, and tests using phototransister (PT) and spring (ST) recorders. Significant decreases in motor activities were observed in the GNS 100mg/kg treated groups in the HC test and in 400 mg/kg treated mice in the PT test. Significant increases of motor activity were absent in both HC and PT tests, however, 10 mg/kg of GNo. 4 and TRg slightly increased locomotor activity in the PT test. A significant increase of locomotor activity in the ST test, was noted after the administration of GNo. 5 at a dose of 10 mg/kg. In the test using an activity wheel apparatus, GRg slightly decreased the number of light beam interruptions, and locomotor and rotating activities in the PT test. GF4 significantly increased the number of interruptions in the activity wheel, and decreased both activities in the PT test. Ten mg/kg of GNo. 3 and GNo. 5 significantly increased locomotor activity of the exercised mice.