Fenoprofen: Inhibitor of prostaglandin synthesis

Fenoprofen, an anti-inflammatory agent, is a potent inhibitor of prostaglandin synthesis at physiological substrate concentration. I 50's of 1 μM to 100 μM were obtained when the concentration of arachidonate was increased from 1 μM to 82 μM. In contrast, a small change in I 50 was observed wit...

Full description

Saved in:
Bibliographic Details
Published in:Basic research in cardiology 1974-03, Vol.6 (2), p.107-113
Main Authors: Ho, Peter P.K., Esterman, Michail A.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Arachidonic Acids - metabolism
Cattle
In Vitro Techniques
Indomethacin - pharmacology
Kinetics
Microsomes - drug effects
Mixed Function Oxygenases - metabolism
Multienzyme Complexes - metabolism
Phenyl Ethers - pharmacology
Propionates - pharmacology
Prostaglandins - biosynthesis
Stimulation, Chemical
Tritium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fenoprofen, an anti-inflammatory agent, is a potent inhibitor of prostaglandin synthesis at physiological substrate concentration. I 50's of 1 μM to 100 μM were obtained when the concentration of arachidonate was increased from 1 μM to 82 μM. In contrast, a small change in I 50 was observed with indomethacin. Kinetic studies indicated that inhibition by fenoprofen was competitive while that of indomethacin was non-competitive.
ISSN:0090-6980
0300-8428
DOI:10.1016/0090-6980(74)90022-7