A syndrome featuring defects of the heart, sternum, diaphragm, and anterior abdominal wall

Three patients featuring a syndrome of defects of the heart, sternum, diaphragm, and anterior abdominal wall are presented. The striking similarity of the anomalies manifested by the 3 cases posed a question whether or not a recognized syndrome previously existed. In order to determine this, a searc...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1959-09, Vol.20 (3), p.396-404
Main Authors: CRITTENDEN, I H, ADAMS, F H, MULDER, D G
Format: Article
Language:English
Subjects:
Abdominal Muscles
Abdominal Wall - abnormalities
Diaphragm - abnormalities
Heart Defects, Congenital - complications
Humans
Old Medline
Sternum - abnormalities
Syndrome
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Summary:Three patients featuring a syndrome of defects of the heart, sternum, diaphragm, and anterior abdominal wall are presented. The striking similarity of the anomalies manifested by the 3 cases posed a question whether or not a recognized syndrome previously existed. In order to determine this, a search was made to find other such cases, and an attempt was made to establish a common embryologic pathogenesis. Review of the literature as well as extensive personal communication was carried out. Embryology of the involved organs was considered in order to determine a specific phase of defective development.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.20.3.396