Histocompatibility (HL‐A) antigens and lymphocytotoxic antibodies in systemic lupus erythematosus (SLE)

Comparison was made of HL‐A phenotypes in 122 patients with systemic lupus erythematosus (SLE) and 1289 ethnically matched controls. The only significant association was between the HL‐A antigen HL‐A5 and the presence of SLE in Black Americans. A similar trend in 40 Caucasian patients did not reach...

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Bibliographic Details
Published in:Arthritis and rheumatism 1974-07, Vol.17 (4), p.397-402
Main Authors: Nies, Kenneth M., Brown, John C., Dubois, Edmund L., Quismorio, Francisco P., Friou, George J., Terasaki, Paul I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antilymphocyte Serum - analysis
Black or African American
Black People
Complement System Proteins - analysis
Ethnicity
Female
Histocompatibility Antigens - analysis
Histocompatibility Testing
Humans
In Vitro Techniques
Leukopenia - etiology
Leukopenia - immunology
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - immunology
Male
Mexico
Middle Aged
Phenotype
United States
White People
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Summary:Comparison was made of HL‐A phenotypes in 122 patients with systemic lupus erythematosus (SLE) and 1289 ethnically matched controls. The only significant association was between the HL‐A antigen HL‐A5 and the presence of SLE in Black Americans. A similar trend in 40 Caucasian patients did not reach a level of statistical significance. No significant association was present between any HL‐A antigen and clinical or laboratory manifestations of the disease. Lymphocytotoxic antibodies were present in 36% of the patients and correlated with the presence of low total hemolytic complement and leukopenia.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780170409