Operator and promoter are separate in the tryptophan operon in Salmonella typhimurium

Studies of the trp mRNA made by Salmonella typhimurium strains carrying trpOA and trpOAB multisite mutations have shown that these are deletions. They do not extend into the trp promoter ( trpP1 ) as shown by their ability to recombine with trpP4 mutation. Thus the trp operator ( trpO ) and the trp...

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Bibliographic Details
Published in:Nature (London) 1974-09, Vol.251 (5471), p.119-123
Main Authors: Aono, Hiroyuki, Angelosanto, Frank, Balbinder, Elias
Format: Article
Language:English
Subjects:
Carbon Radioisotopes
Centrifugation, Density Gradient
Chromosome Mapping
Genes
Humanities and Social Sciences
Kinetics
multidisciplinary
Mutation
Nucleic Acid Hybridization
Operon
Recombination, Genetic
Rifampin - pharmacology
RNA, Messenger - analysis
RNA, Messenger - biosynthesis
Salmonella typhimurium - metabolism
Science
Science (multidisciplinary)
Transcription, Genetic - drug effects
Tritium
Tryptophan - metabolism
Tryptophan Synthase - biosynthesis
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Summary:Studies of the trp mRNA made by Salmonella typhimurium strains carrying trpOA and trpOAB multisite mutations have shown that these are deletions. They do not extend into the trp promoter ( trpP1 ) as shown by their ability to recombine with trpP4 mutation. Thus the trp operator ( trpO ) and the trp promoter are seperable and arranged in the order P1-O-A .
ISSN:0028-0836
1476-4687
DOI:10.1038/251119a0