Novel Synthesis of Bifunctional Acid-Esters

A novel method was developed for the synthesis of acid-esters via monodemethylation of a dimethyl ester by 1,1-dimethylhydrazine and subsequent conversion of the resulting trimethylhydrazonium ester to the desired acid-ester. The method is facile and seems to have a wide range of applicability.

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1974-07, Vol.63 (7), p.1155-1157
Main Authors: Kasina, Sudhakar, Ng, Kim Wah, Nematollahi, Jay
Format: Article
Language:English
Subjects:
1,1-Dimethylhydrazine—utilized in novel synthesis of bifunctional acid-esters
1-dimethylhydrazine and a dimethyl ester and conversion of the resulting trimethylhydrazonium ester
1-Dimethylhydrazine-utilized in novel synthesis of bifunctional acid-esters
Acid-esters
Acid-esters, bifunctional—novel synthesis using 1,1-dimethylhydrazine and a dimethyl ester and conversion of the resulting trimethylhydrazonium ester
bifunctional-novel synthesis using 1
Carboxylic Acids - chemical synthesis
Esters - analysis
Esters - chemical synthesis
Hydrazines
Indicators and Reagents
Magnetic Resonance Spectroscopy
Mass Spectrometry
Methods
Pyridines
Spectrophotometry, Infrared
Trimethylhydrazonium ester-intermediate in synthesis of bifunctional acid-esters
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Description
Summary:A novel method was developed for the synthesis of acid-esters via monodemethylation of a dimethyl ester by 1,1-dimethylhydrazine and subsequent conversion of the resulting trimethylhydrazonium ester to the desired acid-ester. The method is facile and seems to have a wide range of applicability.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600630731