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7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources

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Bibliographic Details
Published in:	Biochemistry (Easton) 1974-09, Vol.13 (19), p.3899-3903
Main Authors:	Coward, James K, Parameswaran, K. N, Cashmore, Arlene R, Bertino, Joseph R
Format:	Article
Language:	English
Subjects:	Animals Erythrocytes - enzymology Folic Acid - analogs & derivatives Folic Acid - chemical synthesis Folic Acid - metabolism Humans Kinetics Leukemia L1210 - enzymology Leukemia, Lymphoid - enzymology Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - enzymology Methotrexate - therapeutic use Mice Oxidation-Reduction Polycythemia Vera - blood Polycythemia Vera - drug therapy Polycythemia Vera - enzymology Spleen - enzymology Structure-Activity Relationship Tetrahydrofolate Dehydrogenase - blood Tetrahydrofolate Dehydrogenase - metabolism
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