Pseudohermaphroditism, nephron disorder and wilms' tumor: a unifying concept

We have observed three infants and learned of two other previously unreported cases presenting with various combinations of pseudohermaphroditism, Wilms' tumor and nephron disorders including nephrotic syndrome. The concurrence of these disorders, as described in our cases and others from the l...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1974-09, Vol.54 (3), p.366-369
Main Authors: Barakat, A Y, Papadopoulou, Z L, Chandra, R S, Hollerman, C E, Calcagno, P L
Format: Article
Language:English
Subjects:
Birth Weight
Cryptorchidism - diagnosis
Disorders of Sex Development - complications
Disorders of Sex Development - diagnosis
Disorders of Sex Development - embryology
Female
Humans
Hypospadias - diagnosis
Infant
Infant, Newborn
Male
Nephrosis - complications
Nephrosis - embryology
Peritoneal Dialysis
Pneumonia - diagnosis
Urine - analysis
Wilms Tumor - complications
Wilms Tumor - diagnosis
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Summary:We have observed three infants and learned of two other previously unreported cases presenting with various combinations of pseudohermaphroditism, Wilms' tumor and nephron disorders including nephrotic syndrome. The concurrence of these disorders, as described in our cases and others from the literature, indicates that they may have teratogenic origins in common and that all of them originate when pseudohermaphroditism does; namely, during embryogenesis.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.54.3.366