Delayed Hypersensitivity in Hepatitis B: Clinical Correlates of in Vitro Production of Migration Inhibition Factor

Delayed hypersensitivity to hepatitis B surface antigen (HBsAg) in patients with disease from the clinical spectrum of hepatitis and in controls was examined by an indirect assay of macrophage migration inhibitory factor. Activity was demonstrated in cases of acute or persistently active hepatitis....

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Bibliographic Details
Published in:The Journal of infectious diseases 1974-12, Vol.130 (6), p.580-587
Main Authors: Irwin, Gilbert R., Hierholzer, Walter J., Cimis, Robert, McCollum, Robert W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Animals
Antigens
Ascitic Fluid - cytology
Blood
Carrier State
Cell Migration Inhibition
Delayed hypersensitivity
Epidemiology
Female
Guinea Pigs - immunology
Hepatitis
Hepatitis antigens
Hepatitis B
Hepatitis B - diagnosis
Hepatitis B - drug therapy
Hepatitis B - immunology
Hepatitis B Antigens
Humans
Hypersensitivity, Delayed - immunology
Liver
Liver - pathology
Lymphocytes
Lymphocytes - immunology
Macrophage Migration-Inhibitory Factors - analysis
Macrophages - immunology
Major Articles
Male
Middle Aged
Pregnancy
Steroids
Steroids - therapeutic use
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Description
Summary:Delayed hypersensitivity to hepatitis B surface antigen (HBsAg) in patients with disease from the clinical spectrum of hepatitis and in controls was examined by an indirect assay of macrophage migration inhibitory factor. Activity was demonstrated in cases of acute or persistently active hepatitis. Steroids and pregnancy had a suppressive effect. Samples from a patient with transfusion-related HBsAg hepatitis were also assayed.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/130.6.580