The search for a viral agent in Hodgkin's disease

Methods previously employed to implicate viral agents and mycoplasma in the etiology of leukemia and Burkitt's lymphoma were employed in a search for the cause of Hodgkin's disease. In a prospective study of 26 patients, 34% had evidence of “C‐type” particles in tissues or plasma pellets....

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Bibliographic Details
Published in:Cancer 1974-10, Vol.34 (4), p.1080-1089
Main Authors: Hirshaut, Yashar, Reagan, Reginald L., Perry, Seymour, De Vita, Vincent, Barile, Michael F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Viral - analysis
Blood - microbiology
Child
Fluorescent Antibody Technique
Herpesviridae - immunology
Hodgkin Disease - microbiology
Humans
Microscopy, Electron
Middle Aged
Mycoplasma - isolation & purification
Prospective Studies
Retroviridae - isolation & purification
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Summary:Methods previously employed to implicate viral agents and mycoplasma in the etiology of leukemia and Burkitt's lymphoma were employed in a search for the cause of Hodgkin's disease. In a prospective study of 26 patients, 34% had evidence of “C‐type” particles in tissues or plasma pellets. No budding virus was seen. Antibody to the herpes‐like virus (HLV or EBV) was as prevalent in normal controls as in patients with Hodgkin's disease and the frequency of elevated anti‐HLV titers was similar. No mycoplasma was found in 41 specimens from 27 patients examined. There is no firm evidence to date linking Hodgkin's disease to the viruses known to be responsible for animal leukemias or to HLV which is suspected to be the cause of Burkitt's lymphoma. Mycoplasma, a common contaminant in leukemia tissue, is rarely present in the malignant tissues of patients with Hodgkin's disease.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197410)34:4<1080::AID-CNCR2820340418>3.0.CO;2-N