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Octopamine receptors on Aplysia neurones mediate hyperpolarisation by increasing membrane conductance
OCTOPAMINE is a phenylethylamine synthesised by β-hydroxylation of tyramine and differs from noradrenaline in lacking one hydroxyl group on the phenyl ring. Although Aplysia nervous tissue, like that of most molluscs, contains little or no noradrenaline 1,2 , it has between 0.20 and 1.85 pmol octopa...
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| Published in: | Nature (London) 1974-12, Vol.252 (5483), p.483-485 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c2270-8d1f1356b108041b3b965602b72648b205641488b705aecbffcfd904ef26fc913 |
| container_end_page | 485 |
| container_issue | 5483 |
| container_start_page | 483 |
| container_title | Nature (London) |
| container_volume | 252 |
| creator | CARPENTER, DAVID O. GAUBATZ, GARY L. |
| description | OCTOPAMINE is a phenylethylamine synthesised by β-hydroxylation of tyramine and differs from noradrenaline in lacking one hydroxyl group on the phenyl ring. Although
Aplysia
nervous tissue, like that of most molluscs, contains little or no noradrenaline
1,2
, it has between 0.20 and 1.85 pmol octopamine per mg of tissue in the various ganglia. Individual identified neurones also contain detectable octopamine and in neurone R14 it reaches 1.5×10
−4
M (ref. 2). Although octopamine-activated adenyl cyclases have been found in
Aplysia
nervous tissue
3
and insects
4,5
, there has been no electrophysiological demonstration of specific octopamine receptors. We now report receptors in the nervous system of
Aplysia
that are most sensitive to octopamine and mediate a hyperpolarising conductance-increase response. This provides further evidence that octopamine can function as a neurotransmitter. |
| doi_str_mv | 10.1038/252483a0 |
| format | article |
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Aplysia
nervous tissue, like that of most molluscs, contains little or no noradrenaline
1,2
, it has between 0.20 and 1.85 pmol octopamine per mg of tissue in the various ganglia. Individual identified neurones also contain detectable octopamine and in neurone R14 it reaches 1.5×10
−4
M (ref. 2). Although octopamine-activated adenyl cyclases have been found in
Aplysia
nervous tissue
3
and insects
4,5
, there has been no electrophysiological demonstration of specific octopamine receptors. We now report receptors in the nervous system of
Aplysia
that are most sensitive to octopamine and mediate a hyperpolarising conductance-increase response. This provides further evidence that octopamine can function as a neurotransmitter.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/252483a0</identifier><identifier>PMID: 4372548</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Cell Membrane - drug effects ; Cell Membrane - physiology ; Electric Stimulation ; Ethanolamines - pharmacology ; Ganglia - drug effects ; Ganglia - physiology ; Humanities and Social Sciences ; In Vitro Techniques ; Iontophoresis ; letter ; Membrane Potentials - drug effects ; Mollusca - physiology ; multidisciplinary ; Neurons - drug effects ; Neurons - physiology ; Norepinephrine - pharmacology ; Octopamine - pharmacology ; Receptors, Drug ; Science ; Science (multidisciplinary) ; Synaptic Transmission - drug effects</subject><ispartof>Nature (London), 1974-12, Vol.252 (5483), p.483-485</ispartof><rights>Springer Nature Limited 1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2270-8d1f1356b108041b3b965602b72648b205641488b705aecbffcfd904ef26fc913</citedby><cites>FETCH-LOGICAL-c2270-8d1f1356b108041b3b965602b72648b205641488b705aecbffcfd904ef26fc913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4372548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CARPENTER, DAVID O.</creatorcontrib><creatorcontrib>GAUBATZ, GARY L.</creatorcontrib><title>Octopamine receptors on Aplysia neurones mediate hyperpolarisation by increasing membrane conductance</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>OCTOPAMINE is a phenylethylamine synthesised by β-hydroxylation of tyramine and differs from noradrenaline in lacking one hydroxyl group on the phenyl ring. Although
Aplysia
nervous tissue, like that of most molluscs, contains little or no noradrenaline
1,2
, it has between 0.20 and 1.85 pmol octopamine per mg of tissue in the various ganglia. Individual identified neurones also contain detectable octopamine and in neurone R14 it reaches 1.5×10
−4
M (ref. 2). Although octopamine-activated adenyl cyclases have been found in
Aplysia
nervous tissue
3
and insects
4,5
, there has been no electrophysiological demonstration of specific octopamine receptors. We now report receptors in the nervous system of
Aplysia
that are most sensitive to octopamine and mediate a hyperpolarising conductance-increase response. This provides further evidence that octopamine can function as a neurotransmitter.</description><subject>Animals</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - physiology</subject><subject>Electric Stimulation</subject><subject>Ethanolamines - pharmacology</subject><subject>Ganglia - drug effects</subject><subject>Ganglia - physiology</subject><subject>Humanities and Social Sciences</subject><subject>In Vitro Techniques</subject><subject>Iontophoresis</subject><subject>letter</subject><subject>Membrane Potentials - drug effects</subject><subject>Mollusca - physiology</subject><subject>multidisciplinary</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Norepinephrine - pharmacology</subject><subject>Octopamine - pharmacology</subject><subject>Receptors, Drug</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synaptic Transmission - drug effects</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><recordid>eNplkDtPwzAURi0EgvKQ-ANImRAMgWvHdtyxQrykSl1gjmz3BlwldrCTof8eoxYWJg_f0dH1IeSSwh2FSt0zwbiqNByQGeW1LLlU9SGZATBVgqrkCTlNaQMAgtb8mBzzqmaCqxnBlR3DoHvnsYhocRhDTEXwxWLotsnpwuMUg8dU9Lh2esTicztgHEKno0t6dBk128J5G1En5z8y15uos84Gv57sqL3Fc3LU6i7hxf49I-9Pj28PL-Vy9fz6sFiWlrEaSrWmLa2ENBQUcGoqM5dCAjM1k1wZBkJyypUyNQiN1rStbddz4Ngy2do5rc7I9c47xPA1YRqb3iWLXZfvCVNqFBO1yIEyeLMDbQwpRWybIbpex21Dofkp2vwWzejV3jmZ3OAP3CfM--1uT3nxHxibTZiiz9_87_oGV4R-4w</recordid><startdate>19741206</startdate><enddate>19741206</enddate><creator>CARPENTER, DAVID O.</creator><creator>GAUBATZ, GARY L.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19741206</creationdate><title>Octopamine receptors on Aplysia neurones mediate hyperpolarisation by increasing membrane conductance</title><author>CARPENTER, DAVID O. ; GAUBATZ, GARY L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2270-8d1f1356b108041b3b965602b72648b205641488b705aecbffcfd904ef26fc913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - physiology</topic><topic>Electric Stimulation</topic><topic>Ethanolamines - pharmacology</topic><topic>Ganglia - drug effects</topic><topic>Ganglia - physiology</topic><topic>Humanities and Social Sciences</topic><topic>In Vitro Techniques</topic><topic>Iontophoresis</topic><topic>letter</topic><topic>Membrane Potentials - drug effects</topic><topic>Mollusca - physiology</topic><topic>multidisciplinary</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Norepinephrine - pharmacology</topic><topic>Octopamine - pharmacology</topic><topic>Receptors, Drug</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synaptic Transmission - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARPENTER, DAVID O.</creatorcontrib><creatorcontrib>GAUBATZ, GARY L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARPENTER, DAVID O.</au><au>GAUBATZ, GARY L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Octopamine receptors on Aplysia neurones mediate hyperpolarisation by increasing membrane conductance</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1974-12-06</date><risdate>1974</risdate><volume>252</volume><issue>5483</issue><spage>483</spage><epage>485</epage><pages>483-485</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>OCTOPAMINE is a phenylethylamine synthesised by β-hydroxylation of tyramine and differs from noradrenaline in lacking one hydroxyl group on the phenyl ring. Although
Aplysia
nervous tissue, like that of most molluscs, contains little or no noradrenaline
1,2
, it has between 0.20 and 1.85 pmol octopamine per mg of tissue in the various ganglia. Individual identified neurones also contain detectable octopamine and in neurone R14 it reaches 1.5×10
−4
M (ref. 2). Although octopamine-activated adenyl cyclases have been found in
Aplysia
nervous tissue
3
and insects
4,5
, there has been no electrophysiological demonstration of specific octopamine receptors. We now report receptors in the nervous system of
Aplysia
that are most sensitive to octopamine and mediate a hyperpolarising conductance-increase response. This provides further evidence that octopamine can function as a neurotransmitter.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4372548</pmid><doi>10.1038/252483a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1974-12, Vol.252 (5483), p.483-485 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | Nature Publishing Group |
| subjects | Animals Cell Membrane - drug effects Cell Membrane - physiology Electric Stimulation Ethanolamines - pharmacology Ganglia - drug effects Ganglia - physiology Humanities and Social Sciences In Vitro Techniques Iontophoresis letter Membrane Potentials - drug effects Mollusca - physiology multidisciplinary Neurons - drug effects Neurons - physiology Norepinephrine - pharmacology Octopamine - pharmacology Receptors, Drug Science Science (multidisciplinary) Synaptic Transmission - drug effects |
| title | Octopamine receptors on Aplysia neurones mediate hyperpolarisation by increasing membrane conductance |
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