Alteration of the Growth of Mammalian Cells in vitro by Ecdysone Extract

IN insects metamorphosis is controlled by a balance between juvenile hormone (neotenin) and metamorphosis hormone (ecdysone) with trophic neurosecretion responsible for periodicity 1–4 . Work on the reason for regression of atypical growths in Drosophila 5 during the larval stage implicated this hor...

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Bibliographic Details
Published in:Nature (London) 1961-02, Vol.189 (4765), p.666-668
Main Authors: BURDETTE, WALTER J., RICHARDS, RALPH C.
Format: Article
Language:English
Subjects:
Animals
Ecdysone
Growth Substances - pharmacology
Humanities and Social Sciences
Humans
In Vitro Techniques
Insecta
letter
multidisciplinary
Old Medline
Physiological Phenomena
Science
Science (multidisciplinary)
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Summary:IN insects metamorphosis is controlled by a balance between juvenile hormone (neotenin) and metamorphosis hormone (ecdysone) with trophic neurosecretion responsible for periodicity 1–4 . Work on the reason for regression of atypical growths in Drosophila 5 during the larval stage implicated this hormonal mechanism in the observed behaviour 6,7 . As a result of this work, investigation of the possibility that hormones in invertebrates may have an effect on mammalian cells is in progress. In earlier work 8 , there were suggestive regressions of transplanted tumours in mice when ecdysone was injected into individuals bearing transplants. Although the large amount of hormone required render this type of testing impractical except on a limited scale, the results were sufficiently encouraging to stimulate additional studies in vitro .
ISSN:0028-0836
1476-4687
DOI:10.1038/189666a0