The nephrotic syndrome in the first year of life

The clinical course of nephrosis in five infants with onset of disease before 7 months of age is presented, together with evaluation of renal lesions seen at necropsy. The problems of the management of nephrosis susceptibility to infection and water and electrolyte imbalance were found to be exagger...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1960-06, Vol.25 (6), p.967-976
Main Authors: PARKER, R A, PIEL, C F
Format: Article
Language:English
Subjects:
Child
Humans
Infant
Nephrotic Syndrome
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Summary:The clinical course of nephrosis in five infants with onset of disease before 7 months of age is presented, together with evaluation of renal lesions seen at necropsy. The problems of the management of nephrosis susceptibility to infection and water and electrolyte imbalance were found to be exaggerated by the young age of the patients. The renal pathology observed in these five infants consisted of persistence of immature glomeruli and dilatation of the tubules in the cortical area. Later, the immature glomeruli and associated tubules appear to atrophy and the remaining glomeruli to hypertrophy. Long-term adrenocorticosteroid therapy seems to be contraindicated, not only on the basis of the pathologic changes, but because it greatly exaggerates the problems of management and does not effect a remission of the disease.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.25.6.967