HL-A Frequencies in Patients with Multiple Sclerosis

The histocompatibility antigens (HL-A) have been determined in 100 multiple sclerosis (M.S.) patients and 143 randomly selected controls. In the M.S. group there was a statistically significant increase in the frequency of HL-A 7 and W 18 with an insignificant increase in HL-A 3. The variance from n...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 1974-11, Vol.1 (4), p.211-213
Main Authors: Paty, D.W., Mervart, H., Campling, B., Rand, C.G., Stiller, C.R.
Format: Article
Language:English
Subjects:
Autoimmune Diseases
Histocompatibility Antigens
HLA Antigens
Humans
Multiple Sclerosis - etiology
Multiple Sclerosis - immunology
Poliomyelitis - complications
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Summary:The histocompatibility antigens (HL-A) have been determined in 100 multiple sclerosis (M.S.) patients and 143 randomly selected controls. In the M.S. group there was a statistically significant increase in the frequency of HL-A 7 and W 18 with an insignificant increase in HL-A 3. The variance from normal HL-A patterns in the M.S. population may play some role in establishing the substrate for this disease. Studies in experimental animals have shown that susceptibility to autoimmune disease and to virus infection is linked to the major histocompatibility locus. This has interesting implications for both the “slow virus” and the “autoimmune” theories of the etiology of multiple sclerosis.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100019788