Regional blood flow and vascular resistance in the spontaneously hypertensive rat

Blood flow through the superior mesenteric and iliac arteries and the ascending aorta was determined electromagnetically in spontaneously hypertensive rats and in two strains of Wistar normotensive rats (Wistar Kyoto and Wistar Carworth). Regional vascular resistance of the mesenteric and hindlimb c...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular research 1974-11, Vol.8 (6), p.758-762
Main Authors: TOBIA, ALFONSO J., LEE, JANG Y., WALSH, GERALD M.
Format: Article
Language:English
Subjects:
Animals
Aorta - physiopathology
Blood Pressure
Carotid Arteries - physiopathology
Catheterization
Electromagnetic Phenomena
Hindlimb - blood supply
Hypertension - genetics
Hypertension - physiopathology
Iliac Artery - physiopathology
Male
Mesenteric Arteries - physiopathology
Rats
Rats, Inbred Strains
Transducers
Vascular Resistance
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood flow through the superior mesenteric and iliac arteries and the ascending aorta was determined electromagnetically in spontaneously hypertensive rats and in two strains of Wistar normotensive rats (Wistar Kyoto and Wistar Carworth). Regional vascular resistance of the mesenteric and hindlimb circulations and total peripheral resistance were calculated from measurements of blood flow and arterial pressure in pentobarbital anaesthetized male rats 5 to 8 months of age. There was no significant difference between the spontaneously hypertensive rats and either normotensive strain in blood flow index (ml./min/kg) of the superior mesenteric and iliac arteries, or of the ascending aorta. Moreover, the hindlimb/mesenteric resistance ratio was unaltered in the spontaneously hypertensive rats relative to the normotensive controls. These data suggest that a proportionate increase in vascular resistance occurs in the hindlimb and mesenteric circulations of the spontaneously hypertensive rats.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/8.6.758