Regional blood flow and vascular resistance in the spontaneously hypertensive rat

• Published in: Cardiovascular research 1974-11, Vol.8 (6), p.758-762
• Main Authors: TOBIA, ALFONSO J., LEE, JANG Y., WALSH, GERALD M.
• Format: Article
• Language: English
• Subjects: Animals; Aorta - physiopathology; Blood Pressure; Carotid Arteries - physiopathology; Catheterization; Electromagnetic Phenomena; Hindlimb - blood supply; Hypertension - genetics; Hypertension - physiopathology; Iliac Artery - physiopathology; Male; Mesenteric Arteries - physiopathology; Rats; Rats, Inbred Strains; Transducers; Vascular Resistance
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1093/cvr/8.6.758

Blood flow through the superior mesenteric and iliac arteries and the ascending aorta was determined electromagnetically in spontaneously hypertensive rats and in two strains of Wistar normotensive rats (Wistar Kyoto and Wistar Carworth). Regional vascular resistance of the mesenteric and hindlimb circulations and total peripheral resistance were calculated from measurements of blood flow and arterial pressure in pentobarbital anaesthetized male rats 5 to 8 months of age. There was no significant difference between the spontaneously hypertensive rats and either normotensive strain in blood flow index (ml./min/kg) of the superior mesenteric and iliac arteries, or of the ascending aorta. Moreover, the hindlimb/mesenteric resistance ratio was unaltered in the spontaneously hypertensive rats relative to the normotensive controls. These data suggest that a proportionate increase in vascular resistance occurs in the hindlimb and mesenteric circulations of the spontaneously hypertensive rats.