Antigenic Analyses of Sequential Isolates of Coxsackie A16 Virus from 1964 to 1970 in Japan

ABSTRACT Biological and serological comparisons of sequential isolates of Coxsackie A16 virus (Cox A16) in 1951 through 1970 were made to elucidate the mode of appearance of the mutant which caused a nationwide epidemic of hand‐foot‐and‐mouth disease (HFMD) in 1970. Most strains isolated from feces...

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Bibliographic Details
Published in:Japanese Journal of Microbiology 1974-06, Vol.18 (6), p.463-467
Main Authors: Fujimiya, Yoshiaki, Suto, Tsunehisa, Morita, Morihiro, Ishida, Nakao
Format: Article
Language:English
Subjects:
Animals
Antigens, Viral - analysis
Cell Line
Child
Cross Reactions
Disease Outbreaks
Enterovirus - immunology
Enterovirus - isolation & purification
Feces - microbiology
Foot-and-Mouth Disease - microbiology
Haplorhini
Humans
Japan
Kidney
Mutation
Neutralization Tests
Viral Plaque Assay
Virus Cultivation
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Summary:ABSTRACT Biological and serological comparisons of sequential isolates of Coxsackie A16 virus (Cox A16) in 1951 through 1970 were made to elucidate the mode of appearance of the mutant which caused a nationwide epidemic of hand‐foot‐and‐mouth disease (HFMD) in 1970. Most strains isolated from feces of healthy children in 1964, 1966 and 1967 were serologically similar to the prototype strain isolated in 1951. However, some strains isolated from these healthy children in 1966 and 1967 were serologically and biologically related more closely to the epidemic strain isolated in 1970. Thus sequential isolates of Cox A16 could be roughly classified into two groups, i.e., the prototype strain‐like and the epidemic strain‐like groups.
ISSN:0021-5139
1348-0421
DOI:10.1111/j.1348-0421.1974.tb00835.x