Effects of Glucose Analogues (2-Deoxy-d-glucose, 2-Deoxy-d-galactose) on Experimental Tumors

The effects of the glucose antagonists, 2-deoxy-d-glucose and 2-deoxy-d-galactose, have been studied on solid, ascitic, and systemic transplantable tumors in mice. Inhibition of tumor growth was noted in each instance and a modest prolongation of survival time attained with most tumors. These effect...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1960-02, Vol.24 (2), p.267-281
Main Authors: Laszlo, John, Humphreys, Stewart R., Goldin, Abraham
Format: Article
Language:English
Subjects:
Animals
Deoxyglucose
Galactose
Glucose - antagonists & inhibitors
Humans
Neoplasms, Experimental
Old Medline
Online Access:Get full text
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Summary:The effects of the glucose antagonists, 2-deoxy-d-glucose and 2-deoxy-d-galactose, have been studied on solid, ascitic, and systemic transplantable tumors in mice. Inhibition of tumor growth was noted in each instance and a modest prolongation of survival time attained with most tumors. These effects were more extensive than those achieved with rigorous caloric restriction alone. The results are considered consistent with the hypothesis that interference with glycolysis at the hexokinase reaction may be inhibitory to tumor growth.
ISSN:0027-8874
1460-2105
1460-2105
DOI:10.1093/jnci/24.2.267