Property of Potassium-Induced Contracture of the Guinea-Pig Tracheal Muscle in Relation to Calcium

High K induced a sustained contracture in guinea-pig tracheal muscle, of which tonic tension level was dependent on the external K and the external Ca concentration. Ca-free-solution, DNP and malonate applied before the high K application completely inhibited the tension development with high K, whe...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1974, Vol.24(4), pp.627-634
Main Authors: Saida, Kooichi, Yanaura, Saizo, Chujyo, Nobuyuki
Format: Article
Language:English
Subjects:
Animals
Calcium - pharmacology
Cold Temperature
Dinitrophenols - pharmacology
Dose-Response Relationship, Drug
Female
Glucose - pharmacology
Guinea Pigs
Hypoxia - physiopathology
In Vitro Techniques
Malonates - pharmacology
Manganese - pharmacology
Muscle Contraction - drug effects
Potassium - antagonists & inhibitors
Potassium - pharmacology
Time Factors
Trachea - drug effects
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Summary:High K induced a sustained contracture in guinea-pig tracheal muscle, of which tonic tension level was dependent on the external K and the external Ca concentration. Ca-free-solution, DNP and malonate applied before the high K application completely inhibited the tension development with high K, whereas these agents partially inhibited the tension when applied during K contracture. Anoxia and glucose-free-solution had little or no effect on K contracture. No phasic contraction was observed under any of the present experimental conditions. The results indicate that the uptake of the extracellular Ca by energy-requiring process is essential for K contracture of tracheal muscle.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.24.627