Identification of a Compound related to 6-Aminopenicillanic Acid, isolated from Culture Media of Penicillium chrysogenum

IT has previously been reported 1 that when a high-yielding strain of Penicillium chrysogenum was grown in shake flasks in a chemically defined arginine–lactose medium 2 containing sodium sulphate labelled with sodium-35 in the absence of phenylacetic acid, a radioactive compound extractable with n...

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Bibliographic Details
Published in:Nature (London) 1961-08, Vol.191 (4791), p.909-910
Main Authors: BALLIO, A, CHAIN, E. B, DENTICE DI ACCADIA, F, MAURI, M, RAUER, K, SCHLESINGER, M. J, SCHLESINGER, SONDRA
Format: Article
Language:English
Subjects:
Culture Media
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Penicillanic Acid
Penicillins - chemistry
Penicillium - metabolism
Penicillium chrysogenum
Science
Science (multidisciplinary)
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Summary:IT has previously been reported 1 that when a high-yielding strain of Penicillium chrysogenum was grown in shake flasks in a chemically defined arginine–lactose medium 2 containing sodium sulphate labelled with sodium-35 in the absence of phenylacetic acid, a radioactive compound extractable with n -butyl-acetate was formed instead of benzylpenicillin. This compound differed in its chromatographic properties from any of the known penicillin degradation products.
ISSN:0028-0836
1476-4687
DOI:10.1038/191909a0