EFFECTS OF HALOTHANE ON DNA SYNTHESIS AND MITOSIS IN ROOT TIP MERISTEMS OF VICIA FABA

Further investigations on cell division and the cell cycle in Vicia faba show that halothane has a depressant effect on cells in all the phases of mitosis and also that it delays or inhibits the passage of cells through “S” and “G2”. An effect on cells in “G1” is not excluded. Comparsion with colchi...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1974-09, Vol.46 (9), p.653-657
Main Authors: GRANT, C.J., POWELL, J.N., RADFORD, SHEILA G.
Format: Article
Language:English
Subjects:
Depression, Chemical
DNA - biosynthesis
Halothane - pharmacology
Mitosis - drug effects
Plant Cells
Plants - drug effects
Plants - genetics
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Summary:Further investigations on cell division and the cell cycle in Vicia faba show that halothane has a depressant effect on cells in all the phases of mitosis and also that it delays or inhibits the passage of cells through “S” and “G2”. An effect on cells in “G1” is not excluded. Comparsion with colchicine emphasizes the widespread effects of halothane in contrast to the stage-specific effect of colchicine. The partial division synchrony induced by a short halothane exposure is discussed.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/46.9.653