GLUCURONIC ACID PATHWAY IN ALLOXAN DIABETIC RABBITS (I) URINARY EXCRETION OF METABOLITES RELATED TO THE GLUCURONIC ACID PATHWAY

Studies on the activity or the glucuronic acid pathway in alloxan diabetic rabbits were carried out. Amount of D-glucaric acid, L-ascorbic acid, and D-glucuronic acid in urine increased in the case of the alloxan diabetic rabbits. The transformation from D-glucuronolactone to D-glucaric acid was hig...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1974, Vol.24(6), pp.869-878
Main Authors: HINOHARA, Yoshikazu, TAKANASHI, Shigeru, NAGASHIMA, Rcnpei, SHIOYA, Akitoshi
Format: Article
Language:English
Subjects:
Adipates - urine
Alcohol Oxidoreductases - metabolism
Animals
Ascorbic Acid - urine
Carbon Radioisotopes
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - urine
Glucuronates - metabolism
Glucuronates - urine
Lactones - metabolism
Liver - enzymology
Male
Rabbits
Sugar Acids - urine
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Summary:Studies on the activity or the glucuronic acid pathway in alloxan diabetic rabbits were carried out. Amount of D-glucaric acid, L-ascorbic acid, and D-glucuronic acid in urine increased in the case of the alloxan diabetic rabbits. The transformation from D-glucuronolactone to D-glucaric acid was higher than normal in the diabetic animals. The expired 14CO32 decreased and urinary excretion of labeled L-gulonic acid increased after administration of 6-14C-glucuronolactone in the diabetic rabbits. L-Gulonic acid dehydrogenase, lactonase II, and β-glucuronidase activities were reduced, and UDPGA-pyrophosphatase, D-glucuronic acid-l-phosphatase, and UDPGA-transferase activities increased in the diabetic rabbit liver. From these results, it may be concluded that an increase of endogenous D-glucuronic acid in the diabetic states could be attributed to a metabolic defect in the step of L-gulonic acid dehydrogenation and to the enhancement of UDPGA-pyrophosphatase and D-glucuronic acid-I -phosphate phosphatase activities.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.24.869