A comparison of soft tissue reaction to silastic and absorbable suture material

Alloplastic implants in reconstructive surgery have many varied applications. The problem of extrusion in certain areas has not been totally resolved. Our intent was to design and develop a composite alloplastic implant which would be fixed to local tissues by fibrous ingrowth. Small amounts, less t...

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Bibliographic Details
Published in:Journal of biomedical materials research 1974, Vol.8 (3), p.127-136
Main Authors: Toranto, I. Richard, Salyer, Kenneth E., Nickell, William B.
Format: Article
Language:English
Subjects:
Animals
Connective Tissue - drug effects
Connective Tissue - surgery
Connective Tissue - ultrastructure
Connective Tissue Cells
Foreign-Body Reaction
Methylmethacrylates - pharmacology
Muscles - drug effects
Muscles - surgery
Muscles - ultrastructure
Polyglycolic Acid - pharmacology
Rats
Silicone Elastomers - pharmacology
Sutures
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Summary:Alloplastic implants in reconstructive surgery have many varied applications. The problem of extrusion in certain areas has not been totally resolved. Our intent was to design and develop a composite alloplastic implant which would be fixed to local tissues by fibrous ingrowth. Small amounts, less than 5% by weight, of a biodegradable substance with either Silicone type A or clear dental acrylic were used. Laboratory rats were implanted subcutaneously with sterile prostheses measuring 21 mm × 1 mm. The biodegradable portion consisted of presently available absorbable suture‐polyglycolic acid, chromic catgut, and plain catgut in small particles. The implants were harvested at six weeks and three months and objectively evaluated for tissue fixation and fibrous reaction. In our model, the composite alloplastic prosthesis of chromic catgut and Silicone type A established superior fixation by fibrous ingrowth with a minimum of fibrous capsular thickness.
ISSN:0021-9304
1097-4636
DOI:10.1002/jbm.820080313