Hemangiosarcoma of spleen with spontaneous rupture

A 76‐year‐old man with spontaneous rupture of a hemangiosarcoma of the spleen, together with a review of 49 previously reported patients with splenic hemangiosarcoma are presented. Twenty‐three were women and 27 were men. All but 3 were adults. Fifteen were 50–59 years of age. The symptomatology was...

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Bibliographic Details
Published in:Cancer 1975-02, Vol.35 (2), p.534-539
Main Authors: Autry, Johnna Russell, Weitzner, Stanley
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anemia, Hemolytic - etiology
Child
Child, Preschool
Female
Hemangiosarcoma - complications
Hemangiosarcoma - diagnosis
Hemorrhage - etiology
Humans
Infant
Liver Neoplasms
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Metastasis
Prognosis
Splenectomy
Splenic Neoplasms - complications
Splenic Neoplasms - diagnosis
Splenic Rupture - etiology
Splenic Rupture - surgery
Splenomegaly - etiology
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Summary:A 76‐year‐old man with spontaneous rupture of a hemangiosarcoma of the spleen, together with a review of 49 previously reported patients with splenic hemangiosarcoma are presented. Twenty‐three were women and 27 were men. All but 3 were adults. Fifteen were 50–59 years of age. The symptomatology was nonspecific. Three patients developed microangiopathic hemolytic anemia. Spontaneous rupture occurred in 17 cases (34%). Metastases occurred in 42 cases; they were primarily hematogenous and most often in the liver. Lymph node involvement, however, was present in 13 cases. The prognosis of untreated splenic hemangiosarcoma is poor. Three of 25 patients survived a year or more after the initial onset of symptoms. Splenectomy before rupture is advisable, since 5 of 19 patients survived at least 1–5 years. It is suggested that hemangiosarcoma be considered in patients with: 1) splenomegaly without evidence of malignant lymphoma or leukemia, 2) splenomegaly with microangiopathic hemolytic anemia, and 3) unexplained intraperitoneal hemorrhage.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197502)35:2<534::AID-CNCR2820350236>3.0.CO;2-4