THYMOSIN-INDUCED DIFFERENTIATION OF MURINE THYMOCYTES IN ALLOGENEIC MIXED LYMPHOCYTE CULTURES

Calf thymosin is shown to enhance the one-way MLR of CBA thymocytes cultured with allogeneic mitomycin-C- treated C57BL/J6 spleen cells. Thymosin does not enhance the one-way MLR of CBA thymocytes cultured with syngeneic mitomucin-C-treated spleen cells. Based on this finding we present a relatively...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1975-02, Vol.249 (1), p.145-153
Main Authors: Cohen, Geraldine H., Hooper, John A., Goldstein, Allan L.
Format: Article
Language:English
Subjects:
Animals
Bone Marrow - immunology
Bone Marrow Cells
Bucladesine
Cell Differentiation
Erythropoietin
Escherichia coli - immunology
Humans
Lipopolysaccharides
Lymph Nodes - cytology
Lymphocyte Culture Test, Mixed
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mitomycins
Polysaccharides, Bacterial
Serum Albumin, Bovine
Spleen - cytology
T-Lymphocytes - immunology
Thymosin - pharmacology
Thymus Extracts - pharmacology
Thymus Gland - cytology
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Summary:Calf thymosin is shown to enhance the one-way MLR of CBA thymocytes cultured with allogeneic mitomycin-C- treated C57BL/J6 spleen cells. Thymosin does not enhance the one-way MLR of CBA thymocytes cultured with syngeneic mitomucin-C-treated spleen cells. Based on this finding we present a relatively simple, rapid and quantitative in vitro microculture hioassay for inducers of T-cell differentiation and propose that thymosin treatment, when accompanied by antigen presentation, induces the two-step maturational sequence of pre-T yields T1 yields T2.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1975.tb29064.x