Evaluation of a Sustained Release Form of Phenylpropanolamine Hydrochloride by Urinary Excretion Studies

The sustained releasing properties of phenylpropanolamine hydrochloride contained in Spansule capsules were evaluated by conducting urinary excretion studies. The average maximum rate of excretion after a unit dose of unprocessed drug was used as a basis of comparison for two sustained release dosag...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1961-03, Vol.50 (3), p.232-237
Main Authors: Heimlich, K.R., MacDonnell, D.R., Flanagan, T.L., O'Brien, P.D.
Format: Article
Language:English
Subjects:
Delayed-Action Preparations
Humans
Old Medline
Phenylpropanolamine
Sympathomimetics - pharmacology
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Summary:The sustained releasing properties of phenylpropanolamine hydrochloride contained in Spansule capsules were evaluated by conducting urinary excretion studies. The average maximum rate of excretion after a unit dose of unprocessed drug was used as a basis of comparison for two sustained release dosage forms. The data on the sustained release preparations were also evaluated statistically.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600500313