Mitotic Arrest by Deuterium Oxide

In marine invertebrate eggs, where cell divisions occur without growth, deuterium oxide produces arrest of, or serious delay in, mitosis and cytokinesis. All stages requiring assembly or operation of mechanical structures in the cytoplasm are sensitive to D$_{2}$O. The block is reversible in some ce...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1960-01, Vol.131 (3392), p.37-39
Main Authors: Gross, Paul R., Spindel, William
Format: Article
Language:English
Subjects:
Cell Division - pharmacology
Cotyledons
Deuterium - pharmacology
Deuterium Oxide
Eggs
Embryos
Fertilization
Indoleacetic acids
Mitosis
Old Medline
Ova
Phenotypes
Sea water
Titration
Water distillation
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Summary:In marine invertebrate eggs, where cell divisions occur without growth, deuterium oxide produces arrest of, or serious delay in, mitosis and cytokinesis. All stages requiring assembly or operation of mechanical structures in the cytoplasm are sensitive to D$_{2}$O. The block is reversible in some cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.131.3392.37