Auto-oxidation of Apomorphine

The auto-oxidation product of apomorphine has been isolated. On the basis of elemental analysis, spectral evidence, as well as solubility and chromatographic behavior, it appears to be devoid of nitrogen, possibly an 8-substituted phenanthrene-3,4-dione. A scheme is suggested for the degradative pro...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1961-03, Vol.50 (3), p.266-267
Main Authors: Kaul, P.N., Brochmann-Hanssen, E.
Format: Article
Language:English
Subjects:
Apnea - chemistry
Apomorphine
Old Medline
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Summary:The auto-oxidation product of apomorphine has been isolated. On the basis of elemental analysis, spectral evidence, as well as solubility and chromatographic behavior, it appears to be devoid of nitrogen, possibly an 8-substituted phenanthrene-3,4-dione. A scheme is suggested for the degradative process. The decomposition product has no emetic property.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600500323