Pharmacological Actions of Some Methoxyindolealkylamines

THE O-methylation of catecholamines has been shown to be an inactivation process 1 , but the recent characterization of melatonin (N-acetyl-5-methoxytryptamine—a potent agent in lightening frog skin) as a methoxy indole 2 indicates that this may not be true with hydroxyindolealkylamines. To investig...

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Bibliographic Details
Published in:Nature (London) 1961-04, Vol.190 (4771), p.179-180
Main Authors: GESSNER, PETER K, McISAAC, WILLIAM M, PAGE, IRVINE H
Format: Article
Language:English
Subjects:
Blood Pressure - pharmacology
Humanities and Social Sciences
Indoles - pharmacology
letter
multidisciplinary
Muscles - pharmacology
Old Medline
Pressure
Psychopharmacology
Science
Science (multidisciplinary)
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Summary:THE O-methylation of catecholamines has been shown to be an inactivation process 1 , but the recent characterization of melatonin (N-acetyl-5-methoxytryptamine—a potent agent in lightening frog skin) as a methoxy indole 2 indicates that this may not be true with hydroxyindolealkylamines. To investigate this possibility, we have compared the actions of a number of methoxyindolealkylamines with their corresponding analogues on smooth muscle, blood pressure and behavioural patterns.
ISSN:0028-0836
1476-4687
DOI:10.1038/190179a0