Heterotransplantation of Theileria parva -infected cells to athymic mice

CONGENITALLY athymic (nude) mice have been used for the heterotransplantation and maintenance of human tumours 1–6 . In many cases aplasia of the thymus is sufficient to allow tumour growth and other immunosuppressive treatments are apparently unnecessary. Here we describe how infected cells taken f...

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Bibliographic Details
Published in:Nature (London) 1975-02, Vol.253 (5492), p.549-550
Main Authors: IRVIN, A. D, STAGG, D. A, KANHAI, G. K, BROWN, C. G. D
Format: Article
Language:English
Subjects:
Animals
Apicomplexa - growth & development
Cattle
Humanities and Social Sciences
Immunosuppression
letter
Lymphocyte Transfusion
Lymphocytes - parasitology
Mice
multidisciplinary
Radiation Chimera
Science
Science (multidisciplinary)
Theileriasis - immunology
Theileriasis - parasitology
Thymus Gland - immunology
Transplantation, Heterologous
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Summary:CONGENITALLY athymic (nude) mice have been used for the heterotransplantation and maintenance of human tumours 1–6 . In many cases aplasia of the thymus is sufficient to allow tumour growth and other immunosuppressive treatments are apparently unnecessary. Here we describe how infected cells taken from a fatal case of East Coast fever (ECF), regularly produced tumour-like masses only in irradiated athymic mice.
ISSN:0028-0836
1476-4687
DOI:10.1038/253549a0